Vetter-Ject is a patented syringe closure for prefilled syringes. It contains an injection needle and is made of three plastic components. Partly, they are produced with 2-component plastic molding technology. Prefilled syringes need to be sterile inside, including the closure and the injection needle. During steam sterilization the steam expands into the inside of the closure to the needle. This through the channels of the grey plastic component, that is steam permeable. These channels in the same time are designed to provide a good grip during opening the closure with the human hand. Vetter-Ject is a tamper-evident syringe closure.